Explanation
The phenomenon of inhibiting the action of thrombin. Including endogenous or administered substances or materials, which are divided into antithrombin and anticoagulant. Antithrombin is a glycoprotein produced by the liver, consisting of 432 amino acids. It contains three disulfide bonds and four possible glycosylation sites. α- Thrombin is the main form of antithrombin found in blood oars, with one oligosaccharide occupying each of its four glycosylation sites. And secondary form β- Thrombin maintains an unoccupied glycosylation site. Antithrombin can inactivate several enzymes of coagulation system. An anticoagulant is a substance used to prevent blood clotting. It contains a variety of different drugs. The commonly used anticoagulant drugs are: ① heparin, which has a strong anticoagulant effect both in vivo and in vitro, inhibits many links in the coagulation process, and its effect is rapid. It can only be administered intravenously; ② Oral anticoagulant drugs are commonly used, such as dicoumarin, warfarin and new anticoagulant. In addition, snake venom thrombolytic agents such as defibrase, antithrombotic enzyme, and thrombin clearing enzyme can dissolve formed thrombi and reopen blood vessels.
Classification
Biomedical materials -> Basics of Biomedical Materials