Explanation

It is also called artificial liver support system. A device that can replace the detoxification, synthesis, metabolism and other functions of the liver. The liver is an extremely important and complex organ in the human body. It is known as a chemical factory. Acute liver failure is a difficult medical disease. artificial liver can temporarily replace the liver function (part) of patients, so that the damaged liver can be repaired or create time for liver transplantation. According to its function, it can be divided into two types: non biological and biological. The former includes hemodialysis (MARS liver dialysis), hemofiltration, blood exchange and hemoperfusion (adsorbent). These technologies and devices have detoxification functions of the liver and have been clinically applied. The other is biological artificial liver. It places the cultured hepatocytes in vitro in a bioreactor, uses the extracorporeal circulation device to introduce the blood of patients with liver failure into the reactor, and conducts material exchange and biological interaction with cells through the semipermeable membrane (hollow fiber). Thus achieving all physiological functions of the liver. Reactors can be divided into the following types, namely hollow fiber type. Flat and single-layer type, perfusion bed type/micro carrier stem, etc. The semi permeable membrane of the reactor white is made of cellulose acetate, polysulfone, polyacrylonitrile, polymethyl methacrylate, polyethylene vinyl alcohol, etc. Can allow substances with a molecular weight of less than 100000 to pass through. Prevent cells and immune globules from spreading and penetrating. It serves as an isolation function. The commonly used cells in the reactor include primary pig liver cells, human liver cells, C3A cells, and human embryonic stem cells.

Classification