Explanation

biological artificial liver is a medical device, which is based on the cultivation of hepatocytes as the core, and simulates the physiological function of the liver by exchanging substances with blood or plasma in a bioreactor. The early biological materials include animal liver tissue homogenate, fresh liver slices and frozen liver cells. These materials are perfused through semipermeable membranes to achieve certain therapeutic effects. However, due to the inability to maintain the activity of liver tissue for a long time, these methods are gradually being abandoned. At present, the biological artificial liver devices used in clinical trials mainly include the following types: hollow fiber reactors and animal hepatocytes: this device combines pig or other animal hepatocytes by using hollow fiber reactors. C3A cell device: It is a device that uses artificially cultured C3A cells and places them in a bioreactor with a stem. Braided capillary tube bioreactor: This device uses human or pig liver cells and has a braided capillary tube bioreactor. One of the core equipment of biological artificial liver is bioreactor. At present, research includes hollow fiber type, plate type/monolayer culture type, perfusion bed type/stem type and suspension type/capsule type. Each type has its advantages and disadvantages. So far, the research of biological artificial liver is still in the second to third phase of clinical research, mainly applied to patients with liver failure. For patients with acute liver failure, biological artificial liver can be used as transitional support for waiting for liver transplantation, or as a means of supporting some patients with acute liver failure to regenerate their own liver.

Classification