Explanation

When the materials is in direct contact with blood, its interaction with blood will not cause coagulation or thrombosis, and will not damage the ability and nature of blood composition and function. It involves both the effect of materials on blood and the influence of blood on materials. Biological reaction is usually used to judge the Wood compatibility of a medical materials from its anticoagulant ability and not damaging the blood composition and function. The former refers to the ability of surface of materials to inhibit the formation of blood clots in blood vessels, while the latter refers to the influence of materials on blood physiological functions such as hemolysis (destruction of red blood cells), reduction of platelet number and function, temporary reduction of blood cells, decline of white blood cell function, and activation of complement. In addition, materials shall not denature plasma proteins, affect the activities of various enzymes in the blood, change the concentration of elonrolyte in the blood, or cause harmful immune reactions. At present, coagulation and hemolysis are the main contents of Wood compatibility evaluation of biological materials. It includes the physical and chemical properties of surface of materials, competitive adsorption of plasma protein, adhesion and activation of platelets, adhesion, deformation and activation of red blood cells and white blood cells, and contact activation or conditioning of endogenous coagulation system. Fiber dissolving system, enzyme and complement system. In addition, multiple methods should be used to evaluate, rather than relying solely on the experimental results of one method.

Classification