Explanation

materials used in drug release system to load drugs and achieve drug controlled release and delivery, organic macromolecule materials, inorganic materials, metallic materials and their composition hybrid materials can all be used as drug carrier. macromolecule carrier materials are generally biodegradation macromolecule with good biocompatibility, including synthetic macromolecule such as polyester, polyanhydride, polycarbonate, polyamino acid, polyester ether, polyphosphate, polyphosphazene, polyorthoester POE and various functional derivatives. From the perspective of bionics, natural polymer polysaccharides, peptides and their derivatives have attracted increasing attention due to their good biocompatibility. According to the needs of drug delivery, the structure, composition and properties of macromolecule can be designed and adjusted: for example, it has hydrophilic, hydrophobic or amphiphilic properties; Electrically neutral or negatively charged in a certain pH range: from simple linear homopolymer to functional products with various structures (block, graft, star, tree, hyperbranched, etc.) and different chemical compositions (such as the introduction of hydroxyl, carboxyl, amino and other groups) to adjust and optimize the physical and chemical properties of materials; Introduce various targeted groups to endow them with organ and cell targeting functions; Attracting environmentally sensitive structures endow them with intelligent response characteristics. In addition to macromolecule materials, other materials used as drug carrier include organic substances with lower molecular weight such as lipids, peptides, inorganic materials such as calcium carbonate, calcium phosphate, mesoporous nano silicon, and metallic materials such as nano gold (mostly surface modified). In addition, many hybrid materials can also be used as drug carrier, such as macromolecule/inorganic hybrid materials, macromolecule/metal hybrid materials, etc.

Classification