It refers to the changes in the internal and external environment that are not involved by the immune system and can be felt by the human body and cause the reaction of tissue cells, organs and the body. It is collectively called irritation. According to the nature of irritation, it can be divided into: ① physical irritation, such as electricity, magnetism, machinery, temperature, sound wave, light, etc.; ② Chemical irritation, such as acid, alkali, drug, etc.; ③ Biological irritation, such as bacteria and viruses; ④ Social psychological irritation, such as emotional excitement, social change, etc. In the field of biological materials research, irritation usually refers to the nonspecific inflammatory reaction in the body caused by one, multiple or continuous contact with a materials-
Biomedical materials -> Basics of Biomedical Materials